Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5534328 | Molecular and Cellular Endocrinology | 2017 | 6 Pages |
â¢Role of AMH/AMHR2 genetic variant in pathogenesis of PCOS remains to be determined.â¢Systematic review and meta-analysis was conducted in the current study.â¢It was found that AMH and AMHR2 appear not be associated with PCOS.
The etiology of polycystic ovaries syndrome (PCOS) is unknown. Studies probing the role of genetic variants of anti-Mullerian hormone (AMH) and its type II receptor (AMHR2) in the pathogenesis of PCOS have yielded inconsistent results. Thus, we performed a systematic review and meta-analysis to determine the role of genetic variants of AMH/AMHR2 in the pathogenesis of PCOS. A systematic search of electronic databases was performed. Statistical analysis was performed using the Comprehensive Meta-Analysis software (Version 3). Pooled Odds Ratios (OR) (95% confidence intervals) were determined to assess the association between genetic variants of AMH/AMHR2 and PCOS. Five studies, involving a total of 2042 PCOS cases and 1071 controls, were included in the meta-analysis. Single nucleotide polymorphisms of AMH and AMHR2 did not appear to confer a heightened risk for PCOS (OR: 0.954, 95% CI: 0.848-1.073; PÂ =Â 0.435; and OR: 1.074, 95% CI: 0.875-1.318; PÂ =Â 0.494, respectively). In this study, genetic variants of AMH or AMHR2 were not found to be associated with a higher risk for PCOS.