Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5534845 | Seminars in Cell & Developmental Biology | 2017 | 8 Pages |
Abstract
The nuclear pore complex (NPC) forms a permeability barrier between the nucleus and the cytoplasm. Molecules that are able to cross this permeability barrier encounter different disordered phenylalanine glycine rich nucleoporins (FG-Nups) that act as a molecular filter and regulate the selective NPC crossing of biomolecules. In this review, we provide a current overview regarding the interaction mechanism between FG-Nups and the carrier molecules that recognize and enable the transport of cargoes through the NPC aiming to understand the general molecular mechanisms that facilitate the nucleocytoplasmic transport.
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Authors
Iker Valle Aramburu, Edward A. Lemke,