Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5534850 | Seminars in Cell & Developmental Biology | 2017 | 6 Pages |
Abstract
Apoptosis is a programmed cell death playing key roles in physiology and pathophysiology of multi cellular organisms. Its nuclear manifestation requires transmission of the death signals across the nuclear pore complexes (NPCs). In strategic sequential steps apoptotic factors disrupt NPCs structure, integrity and barrier ultimately leading to nuclear breakdown. The present review reflects on these steps.
Keywords
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Authors
Victor Shahin,