Article ID Journal Published Year Pages File Type
5534850 Seminars in Cell & Developmental Biology 2017 6 Pages PDF
Abstract

Apoptosis is a programmed cell death playing key roles in physiology and pathophysiology of multi cellular organisms. Its nuclear manifestation requires transmission of the death signals across the nuclear pore complexes (NPCs). In strategic sequential steps apoptotic factors disrupt NPCs structure, integrity and barrier ultimately leading to nuclear breakdown. The present review reflects on these steps.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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