Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5534924 | Seminars in Cell & Developmental Biology | 2017 | 8 Pages |
Abstract
Lung cancer development is a complex and dynamic progression with cancer cell mutations itself and its' orchestrate with the tumor microenvironment. Targeted therapies have been stated to heterogeneous lung cancer mutations while have a modest consequence. The tumor immune microenvironment influences lung cancer outcome by balancing the suppressive versus cytotoxic responses. The immune microenvironment heterogeneity may play an important role in lung cancer heterogeneity. In this review, we summarized the immune cells, its related cytokines and partial immune genes diversity in tumor microenvironment and its targeted potential mono and combined therapies. It will help us to make better understand the lung cancer heterogeneity and mechanisms of the drug resistance to find a way out.
Keywords
FOXO3CTLA-4Cytotoxic T lymphocyte-associated antigen 4MDSCOPNGRP78PGE2CAFPD-1PFsOsteopontinprogression-free survivalTILTAMforkhead box O3Lung cancerNSCLCNon-small cell lung cancerDendritic cellNatural killer cellmyeloid-derived suppressor cellMIFMacrophage migration inhibitory factorcancer associated fibroblastTumor-associated macrophageProgrammed death-1Tumor microenvironmentglucose-regulated protein 78Prostaglandin E2Squamous cell lung carcinomaLUSC
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Authors
Lingyan Wang, Bijun Zhu, Miaomiao Zhang, Xiangdong MD, PhD,