Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5534950 | Seminars in Cell & Developmental Biology | 2017 | 11 Pages |
Abstract
The liver and pancreas are the prime digestive and metabolic organs in the body. After emerging from the neighboring domains of the foregut endoderm, they turn on distinct differentiation and morphogenesis programs that are regulated by hierarchies of transcription factors. Members of SOX family of transcription factors are expressed in the liver and pancreas throughout development and act upstream of other organ-specific transcription factors. They play key roles in maintaining stem cells and progenitors. They are also master regulators of cell fate determination and tissue morphogenesis. In this review, we summarize the current understanding of SOX transcription factors in mediating liver and pancreas development. We discuss their contribution to adult organ function, homeostasis and injury responses. We also speculate how the knowledge of SOX transcription factors can be applied to improve therapies for liver diseases and diabetes.
Keywords
MafACDX2SOX4IRESSOX17TβRIIHHEXHPDHIF1αHmgPdx1PKD2ENURbpjκPTF1AN-ethyl-N-nitrosoureaNkx6.1Ngn3Foxa3HNF6caudal type homeobox 2Sox9HPCTGFβFGFCDEBDLAAV3,5-diethoxycarbonyl-1,4-dihydrocollidineddCPancreatic and duodenal homeobox 1BACMdm2neuroDSOxBiliary atresiaRegenerationTransforming Growth Factor BetaDifferentiationARXCampomelic dysplasiainternal ribosome entry sitehepatic progenitor cellhypoxia-inducible factor 1 alphafibroblast growth factorhairy and enhancer of split 1mouse double minute 2 homologNeurogenin 3Hes1HomeostasisAdeno-associated virusPancreatic polypeptidebile duct ligationbacterial artificial chromosome
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Authors
Chunyue Yin,