Hepatitis B vaccine and the need for a booster dose after primary vaccination

In conclusion, our findings show that over 25% of HBV vaccine recipients had an antiHBs titer <10 mIU/ml after 18 years of more from the primary vaccination. Furthermore, in the case a booster dose would be needed, our results suggest that the vaccination strategy should prefer administration of a vaccine adult dose during early adolescence, since it might offer longer-term protection through adulthood.