Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5536660 | Vaccine | 2017 | 6 Pages |
Abstract
Our data showed that a combination of PCEP and inactivated virus is capable of inducing a robust and long lasting antibody response. Moreover, significant enhancement of IFN-γ, IFN-α, IL-12(p40) and IL-6 gene expression under the influence of PCEP suggests that as an in ovo adjuvant PCEP has the ability to activate a substantial balanced immune response in chickens. To our knowledge, these are the first studies in which PCEP and ABD have been characterized as adjuvants for the development of an in ovo poultry vaccine. It is expected that these preliminary studies will be helpful in the development of safer and more effective in ovo vaccine against IBH and other infectious diseases affecting chickens.
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Authors
Mishal Sarfraz, Muhammed Suleman, Suresh K. Tikoo, Colette Wheler, Andrew A. Potter, Volker Gerdts, Arshud Dar,