Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5537391 | Vaccine | 2016 | 4 Pages |
Abstract
We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.
Keywords
PRNconventional DCRegulated on Activation, Normal T Expressed and SecretedIRF7Plasmacytoid DCFHANVRIRFPBSLVRPrPTLRMYD88IFN-αFBSPBMCAPCPDCCDCFilamentous haemagglutininPertussis toxoiddiphtheria toxoidtetanus toxoidToll-like receptorfetal bovine serumperipheral blood mononuclear cellsantigen presenting cellmyeloid differentiation factor 88MHCmajor histocompatibility complexPhosphate-buffered salineRANTESPertactin
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Naveen Surendran, Ted Nicolosi, Michael Pichichero,