Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5537403 | Vaccine | 2016 | 10 Pages |
Abstract
This study presents evidence of sieve effects in Gag and Nef; however could not confirm effects on specific amino acid sites. We propose that this weaker signal of vaccine immune pressure detected in the Phambili study compared to the Step study may have been influenced by differences in host genetics (HLA allele frequency) and reduced impact of vaccine-induced immune responses due to mismatch between the viral subtype in the vaccine and infecting subtypes.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
T. Hertz, M.G. Logan, M. Rolland, C.A. Magaret, C. Rademeyer, A. Fiore-Gartland, P.T. Edlefsen, A. DeCamp, H. Ahmed, N. Ngandu, B.B. Larsen, N. Frahm, J. Marais, R. Thebus, D. Geraghty, J. Hural, L. Corey, J. Kublin, C. Williamson,