Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5546140 | Current Opinion in Virology | 2017 | 7 Pages |
Abstract
Human cytomegalovirus causes disabling congenital disease in neonates and severe complications in immunocompromised individuals, making it a high priority for vaccine development. A prophylactic vaccine needs to outperform natural immunity and a therapeutic vaccine needs to elicit rapid protective antiviral responses. This review highlights the three major approaches undertaken by vaccine developers-virus-derived, protein subunit, and gene-based approaches. Each approach offers a unique promise for a successful vaccine by eliciting either a broad immune response or inducing neutralizing antibody responses order(s) of magnitudes greater than natural immunity. A vaccine-elicited immunity is anticipated to have the robustness and duration sufficient to overcome cytomegalovirus infection.
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Authors
Kate Luisi, Mayuri Sharma, Dong Yu,