| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5546238 | Current Opinion in Virology | 2017 | 7 Pages |
â¢Human norovirus productively infects B cells and human enteroid monolayers in vitro.â¢The mouse model provides a valuable tool to study norovirus transmission.â¢Determinants of transmissibility of noroviruses are poorly characterized.â¢New culture and animal models allow addressing some essential knowledge gaps.
Human norovirus is a leading cause of gastroenteritis and is efficiently transmitted between humans and around the globe. The burden of norovirus infections in the global community and in health-care settings warrant the availability of outbreak prevention strategies and control measures that are tailored to the pathogen, outbreak setting and population at risk. A better understanding of viral and host determinants of transmission would aid in developing and fine-tuning such efforts. Here, we describe mechanisms of transmission, available model systems for studying norovirus transmission and their strengths and weaknesses as well as future research strategies.
