Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5552645 | Biomedicine & Pharmacotherapy | 2017 | 8 Pages |
Abstract
Alpinumisoflavone (AIF), a naturally occurring flavonoid compound exacted from Derris eriocarpa, has been found to have a number of pharmacological activities. However, its role in bone disorder has not been investigated. The aim of this study is to evaluate the osteoprotective effect of AIF on ovariectomy-induced bone loss in mice model and related underlying mechanisms. Our study provides experimental evidence that AIF could regulate the remodeling process of bone and exert osteoprotective effect against ovariectomy-induced bone loss. Moreover, our results show that AIF suppresses osteoclast differentiation by attenuating RANKL-induced activation of p38, ERK and JNK pathways and consequently represses the expression of c-Fos and NFATc1.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Oncology
Authors
Wei Cong, Chao Zhou, Jun Yin,