| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5552792 | Biomedicine & Pharmacotherapy | 2017 | 6 Pages |
Abstract
Sporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. The present study investigated the prevalence of the Y282D variant of the GCM2 gene and its association with clinical parameters in patients with a definitive histological diagnosis of sporadic parathyroid carcinoma (SPC) or atypical adenoma (AA).
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Authors
Elena Marchiori, Maria Rosa Pelizzo, Monika Herten, Danyelle M. Townsend, Domenico Rubello, Isabella Merante Boschin,