Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5553088 | Biomedicine & Pharmacotherapy | 2017 | 11 Pages |
Abstract
Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2 mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p = 0.0001, p < 0.001, p = 0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.
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Authors
Gulcin Tezcan, Mevlut Ozgur Taskapilioglu, Berrin Tunca, Ahmet Bekar, Hilal Demirci, Hasan Kocaeli, Secil Ak Aksoy, Unal Egeli, Gulsah Cecener, Sahsine Tolunay,