Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5553142 | Biomedicine & Pharmacotherapy | 2017 | 10 Pages |
Abstract
In these studies anticancer activity of natural occurring flavones, baicalein and luteolin was investigated in colon cancer cells LoVo and in their drug resistant subline LoVo/Dx. Inhibitory activity of these flavones on cells growth and their ability to induce apoptosis were observed. A less pronounced influence of studied flavones on proliferation and apoptosis of LoVo/Dx as compared with LoVo cells well correlated with significantly lower cytotoxicity of these compounds in drug-resistant cells. These effects may be related to overexpression of multidrug transporter P-glycoprotein in drug-resistant LoVo/Dx cells. Our studies indicated that baicalein could be a substrate of this drug transporter.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Oncology
Authors
Anna Palko-Labuz, Kamila Sroda-Pomianek, Anna Uryga, Edyta Kostrzewa-Suslow, Krystyna Michalak,