| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5553277 | Biomedicine & Pharmacotherapy | 2017 | 5 Pages |
Abstract
Bioassay-guided fractionation of the aerial part of P. cablin revealed that fraction A3 of the water extract exhibited significant xanthine oxidase inhibitory activities (IC50 = 85.42 ± 1.71 μg/mL), which further led to the isolation of ten more bioactive compounds, including two new compounds (1 and 2). The structures of compounds 1 and 2 were elucidated by extensive spectral analysis. It is revealed that flavonoids and phenolic compounds were found to be responsible for the xanthine oxidase inhibitory activities of P. cablin. Especially, rosmarinic acid was found to be with potent XO inhibitory activity (IC50 = 8.53 ± 0.91 μg/mL).
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Authors
Fang Liu, Chao Deng, Wei Cao, Guangyao Zeng, Xu Deng, Yingjun Zhou,