Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats

This study investigated the effect of saponins (20-100 mg/kg) from Tithonia diversifolia leaf (STD) on the liver, kidney, heart, lipid profile and hematological parameters of normal rats. The results showed that STD (20-100 mg/kg) though caused a slight increase in the liver, heart and kidney activity of ALT, AST, ALP and GGT (p < 0.05), did not result in corresponding increase in the serum level of these enzymes. A significant reduction in the level of triglycerides, LDL and cholesterol, creatinine, urea, LDH, PCV and hemoglobin were observed with a concomitant increase in HDL, white blood cell and lymphocyte. These study demonstrated the role of STD in enhancing immune response and in reducing cholesterol and triglycerides in normal rats at studied dosages.