Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5554914 | European Journal of Pharmacology | 2017 | 32 Pages |
Abstract
Inflammation is a defensive response against various harmful stimuli and stress conditions, such as tissue injury and one of the most common pathological processes occurring in human diseases. Theaflavin-3,3â²-digallate, one of the theaflavins present in black tea, exhibits several bioactive properties, including the ability to lower the incidence of coronary heart disease, a positive effect on the bone mineral density, and the ability to prevent cancer. The aim of this study was to evaluate whether theaflavin-3,3â²-digallate could reduce the production of pro-inflammatory cytokines in vivo and in vitro and ameliorate acute lung injury (ALI) in a mouse model. In this study, we demonstrated that theaflavin-3,3â²-digallate suppressed the lipopolysaccharide (LPS)-induced phosphorylation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase in RAW 264.7 macrophages. In addition, we also showed that theaflavin-3,3â²-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells. Furthermore, theaflavin-3,3â²-digallate treatment attenuated the severity of LPS-induced ALI in mice. These results suggested that theaflavin-3,3â²-digallate might be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Yanting Wu, Fujun Jin, Yiliang Wang, Feng Li, Lu Wang, Qiaoli Wang, Zhe Ren, Yifei Wang,