| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5558436 | Toxicology and Applied Pharmacology | 2017 | 30 Pages |
Abstract
BA could significantly enhance and reduced HBsAg and HBeAg in hepG2.2.15, a wild-type HBV cell line. Co-treatment of BA and ETV had a more dramatic effect in NA-resistant HBVrtM204V/rtLl80M transfected hepG2 cells. Our study further revealed that BA mainly inhibited the production of HBV RNAs (3.5, 2.4, 2.1 kb), the templates for viral proteins and HBV-DNA synthesis. BA blocked HBV RNAs transcription possibly by down-regulating transcription and expression of HBV replication dependent hepatocyte nuclear factors (HNF1α and HNF4α). Thus, BA may benefit the anti-HBV therapy via inhibiting HBV viral RNAs.
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Authors
Hai Huang, Wei Zhou, Haiyan Zhu, Pei Zhou, Xunlong Shi,