Article ID Journal Published Year Pages File Type
5558909 Vascular Pharmacology 2016 8 Pages PDF
Abstract

Toll-Like receptors (TLRs) are the primary receptors of innate immunity. Considerable evidences have shown that innate immune defence interaction with pro-inflammatory pathways could be through TLRs that in turn leads to development of inflammatory diseases. These TLRs are present on various tissues and cells of cardiovascular system. Previous studies involving SNPs analysis of TLRs demonstrated that TLRs are involved in development and progression of diseases like atherosclerosis, cardiac dysfunction in sepsis and congestive heart failure.In this review, we aimed to bring together the studies which have been conducted previously to establish a link between TLR polymorphism in context to development of cardiovascular diseases (CVD).

Graphical abstractDownload high-res image (140KB)Download full-size image

Related Topics
Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
Authors
, , ,