Experimental study of sucralfate intervention for paraquat poisoning in rats

•It is effective method to treatment the Paraquat poisoning by using Sucralfate.•Sucralfate can decrease the inflammatory response and increase the survival rate.•Compared with Sodium Bicarbonate, Sucralfate shows a more effective result.•Sucralfate can effectively decrease the cytokine (TGF-β1 IL-10 TNF-α) level.•The sucralfate use to treatment poisoning have widely value in future research.

ObjectiveThis study explored the effects of sucralfate intervention as a novel treatment for paraquat (PQ) poisoning in Sprague-Dawley (SD) rats.MethodsAfter PQ poisoning, the SD rats were randomly divided into the PQ control group (treated with normal saline), the sodium bicarbonate (SB) treatment group, and the sucralfate (LTL) treatment group. Then, the rats were administered normal saline, sodium bicarbonate solution, or sucralfate suspension as an intervention by gastric lavage. At 1, 3, 6, and 10 days after poisoning, the left lungs of some rats were removed to determine the lung wet/dry (W/D) weight ratio. Additionally, the serum cytokine levels were measured, and the lung and kidney tissues were pathologically examined.ResultsAfter treatment, the signs and symptoms of the rats were improved, the mortality rate was reduced, the W/D weight ratio of the lung was lower, the cytokine levels [transforming growth factor (TGF)-β1, interleukin (IL)-10, and tumor necrosis factor (TNF)-α] were decreased, and the pathological injuries of the lungs and kidneys were improved. Moreover, sucralfate was significantly more effective than the control (normal saline) group and the SB treatment group.ConclusionThe results showed that early gastrointestinal lavage with sucralfate effectively reduced the inflammatory response and lung and kidney injuries and improved the survival of the SD rats.