Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5559836 | Environmental Toxicology and Pharmacology | 2017 | 21 Pages |
Abstract
The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of consumer products. Investigation of estrogenic and androgenic activities of phthalates (DEP, DBP, BBP, DEHP and DINP) showed no significant effect of tested substances either on hERα or hAR receptors. Phthalates exhibited strong anti-estrogenic (IC50 for BBP = 8.66 μM, IC50 for DEHP = 3.61 μM and IC50 for DINP = 0.065 μM) and anti-androgenic (IC50 for BBP = 5.30 μM, IC50 for DEHP = 2.87 μM and IC50 for DINP = 0.068 μM) activities.
Keywords
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
RadosÅaw Czernych, Milena Chraniuk, PaweÅ Zagożdżon, Lidia Wolska,