Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5559875 | Environmental Toxicology and Pharmacology | 2017 | 26 Pages |
Abstract
In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8Â mg/kg of body weight (bw), 100Â mg/kg-bw and 100Â mg/kg-bw for 28Â days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde levels compared to control. Also, there were statistically significant alterations in liver function tests, lipid profile parameters and histopathological changes in bendiocarb treated groups. Vitamins C and E showed protective effects against examining parameters. According to results we can say that co-treatment of vitamin C and vitamin E may be more effective than use of them alone.
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Authors
Fatma Gökçe Apaydin, Hatice BaÅ, Suna Kalender, Yusuf Kalender,