Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5560960 | NeuroToxicology | 2017 | 9 Pages |
Abstract
The combined neurotoxicity data demonstrate that the different TCPs, including ToCP, are roughly equipotent and a clear structure-activity relation is not apparent for the studied endpoints. The no-observed-effect-concentrations (1 μM) are well above current exposure levels indicating limited neurotoxic health risk, although exposures may have been higher in the past. Moreover, prolonged and/or repeated exposure to TCPs may exacerbate the observed neurotoxic effects, which argues for additional research.
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Authors
Daniel J. Duarte, Joost M.M. Rutten, Martin van den Berg, Remco H.S. Westerink,