Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5561010 | Neurotoxicology and Teratology | 2017 | 10 Pages |
Abstract
Our data are best explained by a model in which isoflurane acutely inhibits mitochondrial function causing activation of responses that ultimately lead to ER-stress. The neurotoxic effect of isoflurane can be completely prevented by manipulations at multiple points in the pathways that control this response. Endogenous signaling pathways can be recruited to protect organisms from the neurotoxic effects of isoflurane.
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Authors
Hyo-Seok MD Phd, Nicole L BA, Katherine R MD, Elyce BS, Margaret M MD, Philip G MD,