Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5561305 | Regulatory Toxicology and Pharmacology | 2016 | 51 Pages |
Abstract
By integrating this evidence, an exposure- and data-based waiving strategy is proposed to determine classification and adequate PPE and to ensure only triggered animal testing is used. Safety characterisation above 2000 mg/kg body weight or 1.0 mg/L air should not be recommended, based on the agrochemical exposure scenarios. The global implementation of these tools would allow a remarkable reduction (up to 95%) in in vivo testing, often inducing lethality and/or severe toxicity, for agrochemical formulations.
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Authors
M. Corvaro, S. Gehen, K. Andrews, R. Chatfield, C. Arasti, J. Mehta,