Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study

Article ID	Journal	Published Year	Pages	File Type
5561697	Toxicology	2017	37 Pages	PDF

Abstract

Our results suggest that the dose-dependent association between prenatal exposure to specific non-dioxin-like PCBs and increases in the H19 and LINE-1 methylation levels in cord blood might be more predominant in females than in males.

Keywords

AHR pentaCB Long interspersed nuclear element-1 dioxin-like polychlorinated biphenyl DL-PCB IGF-2 H19 DMR PCB Polychlorinated biphenyl Gender difference LINE-1 confidence interval Insulin-like growth factor-2 Prenatal exposure DNA methylation Differentially methylated region aromatic hydrocarbon receptor

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study

Authors

Sumitaka Kobayashi, Fumihiro Sata, Chihiro Miyashita, Ryu Miura, Kaoru Azumi, Sachiko Kobayashi, Houman Goudarzi, Atsuko Araki, Mayumi Ishizuka, Takashi Todaka, Jumboku Kajiwara, Tsuguhide Hori, Reiko Kishi,