| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5561850 | Toxicology | 2017 | 31 Pages |
Abstract
These results suggest that CYP2A5 protects against the development of alcoholic fatty liver disease, and the PPARα-FGF21 axis contributes to the protective effects of CYP2A5 on alcoholic fatty liver disease.
Keywords
FR1CYP2A6CYP2A5FGF receptor 1Cytochrome P450 2A5FGF21CYP2E1Cytochrome P450 2A6IRS-1PPARαCyp2e1 knockout miceNrf2KClH&EPI3K/AKTsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGEtriglycerideinsulin receptor substrate 1cytochrome P450 2E1Nuclear factor-erythroid 2-related factor 2fibroblast growth factor 21Hematoxylin and Eosinalcoholic fatty liverPotassium chloridecoumarin 7-hydroxylaseCOHperoxisome proliferator-activated receptor α
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Authors
Xue Chen, Stephen C. Ward, Arthur I. Cederbaum, Huabao Xiong, Yongke Lu,