Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5562062 | Toxicology Letters | 2017 | 24 Pages |
Abstract
Among a variety of metal containing organic compounds, tin derivatives are enjoying an increasing interest and appear to be very promising as potential drug candidates. We studied eight organometallic derivatives, nuclear retinoid X receptor (RXR) ligands and two germanium containing derivates that do not serve as RXR ligands. Tributylgermanium chloride (TBGe) and triphenylgermanium chloride (TPGe) did not inhibit growth of human triple negative MDA-MB-231 breast cancer cells. On the other hand, the tributyltin derivatives were highly, the triphenyltin derivatives less cytotoxic, both groups with IC50 values of nanomolar range. All trialkyltin derivatives (tributyltin chloride, tributyltin bromide, tributyltin iodide, tributyltin hydride) and three triaryltin derivatives (triphenyltin chloride, triphenyltin hydride and triphenyltin hydroxide) caused caspase-3/7 dependent apoptosis. Those derivatives that showed no or weak cytotoxicity, TBGe, TPGe, and triphenyltin acetate, we found to reduce migration of tested triple negative breast cancer cells.
Keywords
FCSTriphenyltin hydroxideTriphenyltin hydrideFDATributyltin chlorideMDA-MB-231RXRRARHER-2Retinoid X receptorSSPMMTVIRS-1PPARAPLERBB2FITCPBSBSADMSOMTTPI 3-kinaseall-trans retinoic acidbovine serum albuminAktStaurosporindocosahexaenoic acidTriphenyltin acetateTriphenyltin chlorideApoptosisDHAfluorescein diacetateDimethylsulfoxideinsulin receptor substrate 1Triple negative breast cancerfetal calf serumCytotoxicityPhosphate buffered salinephosphatidylinositol-3-kinasefluorescein isothiocyanateAPL, acute promyelocytic leukemiaTributyltin hydrideMouse mammary tumor virusprotein kinase B (PKB)Propidium iodideEstrogen receptorHuman epidermal growth factor receptor 2peroxisome proliferator-activated receptor
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Authors
Luba Hunakova, Julius Brtko,