Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5562151 | Toxicology Letters | 2017 | 29 Pages |
Abstract
Nanoparticles exert different cytotoxic effects in the two cell lines, suggesting that the dermal way of exposure is more sensitive than the inhalant way. These differences are most evident in the secretion of pro-inflammatory, angiogenic and proliferative cytokines and chemokines whose expression is more finely modulated in HaCaT cells compared to A-549 cells. Considering the size of these particles, it is important to promote the culture of prevention also for the dermal way in particularly exposed workers.
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Authors
Livia Malorni, Vincenzo Guida, Mariano Sirignano, Giuliana Genovese, Claudia Petrarca, Paola Pedata,