| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5562474 | Toxicology Letters | 2017 | 27 Pages |
Abstract
In conclusion, the AMPH metabolite 4-OHNE is more toxic than 4-OHAMPH, nonetheless both are less toxic than the parent compound in vitro. The most toxic metabolite 4-OHNE has longer permanence in the brain, rendering likely its contribution for AMPH neurotoxicity.
Keywords
MPHVMAT2DAT5-HTTDCFH-DAAMPHNACtPATC50phorbol 12-myristate 13-acetateβ-NADHFBSDMEMCHX3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromideDMSODNADulbecco’s modified Eagle mediumMTTROSAmphetamineattention deficit hyperactivity disorderdeoxyribonucleic acidnon-essential amino acidsDopamine transporternoradrenaline transporterADHDNETDopaminedichlorodihydrofluorescein diacetateDimethyl sulfoxideRetinoic acidfoetal bovine serumserotonin transporterToxicitycycloheximidelactate dehydrogenaseLDHMethylphenidatevesicular monoamine transporter 2noradrenalineN-acetyl cysteineReactive oxygen species
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Authors
R. Feio-Azevedo, V.M. Costa, L.M. Ferreira, P.S. Branco, F.C. Pereira, M.L. Bastos, F. Carvalho, J.P. Capela,