Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations

Article ID	Journal	Published Year	Pages	File Type
5562523	Toxicology in Vitro	2017	10 Pages	PDF

Keywords

OCD MDD GSH FCCP SSRIs IC50 FLX DCFDA TCAs MMP CLM 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT ROS Alamar Blue Antioxidants obsessive-compulsive disorder Major depressive disorders SER analysis of variance ANOVA Oxidative stress Antidepressants tricyclic antidepressants Rh-123 Rhodamine-123 BBB blood brain barrier Sertraline Cytotoxicity Genotoxicity Fluoxetine Mitochondrial complex I selective serotonin reuptake inhibitors Oxygen consumption rates Molecular weight Mitochondrial membrane potential clomipramine Glutathione Reactive oxygen species

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Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations

Authors

Ekramy Elmorsy, Ayat Al-Ghafari, Fahd M. Almutairi, Amal Misbah Aggour, Wayne G. Carter,