| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5562607 | Toxicology in Vitro | 2017 | 46 Pages |
Abstract
Compared to radiometric assays, this high-throughput fluorescent assay is uncomplicated, can measure at physiological conditions, requires no specific facilities and allows for kinetic measurements, enabling detection of transient effects. This assay is therefore a good alternative for radiometric assays to investigate effects of illicit drugs and NPS on monoamine reuptake transporters.
Keywords
25I-NBOMe 1-methyl-4-phenylpyridiniumASP+CFDA-AMRFUBPFα-PVPnorepinephrine transporter3,4-methylenedioxy-N-methylamphetamineMDMA25B-NBOMeMDPVDIMS4-FA2C-BHEKIC505-APBmCPPMXEfFN1-(3-chlorophenyl)piperazineMPP+NPsDopamine transporterDesigner drugsserotonin transporterJARDrug screeningMethoxetamineMethylenedioxypyrovaleroneSelective serotonin reuptake inhibitorSSRINew psychoactive substancesRelative Fluorescence UnitsPMMAhuman embryonic kidney
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Authors
Anne Zwartsen, Anouk H.A. Verboven, Regina G.D.M. van Kleef, Fiona M.J. Wijnolts, Remco H.S. Westerink, Laura Hondebrink,