Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells

Article ID	Journal	Published Year	Pages	File Type
5562755	Toxicology in Vitro	2017	8 Pages	PDF

Keywords

diosbulbin B MLM CYP3A4 TIC CCK MRM UPLC-MS GSH CYP450 FBS SDS DMEM PBS DMF 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide DMSO Dulbecco's modified Eagle Medium MS/MS MTT N,N-dimethylformamide Acetaminophen internal standard dimethyl sulphoxide sodium dodecyl sulfonate fetal bovine serum Cytotoxicity Cytochrome P450 Metabolic activation Reactive metabolite phosphate buffer solution mouse liver microsomes Ketoconazole Glutathione

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells

Authors

Ji-zong Jiang, Bao-hua Yang, Li-li Ji, Li Yang, Yu-Chang Mao, Zhuo-han Hu, Zheng-tao Wang, Chang-hong Wang,