Optimizing Diet, Weight, and Exercise in Adults With Familial Hypercholesterolemia

Familial hypercholesterolemia results in severe elevation of low-density lipoprotein-cholesterol (LDL-c) and is estimated to affect up to 1 in 250 Americans. The rise in LDL-c has implications for the development of atherosclerotic disease and premature death. Treatment starts by its early identification, with careful attention to family history, physical exam, and laboratory analysis. By identifying this disorder, the nurse practitioner can assist the patient in implementing lifestyle changes involving exercise, weight loss, and diet, each impacting LDL-c. For those with familial hypercholesterolemia, each 1% reduction in LDL-c translates to a 3% risk reduction in the development of coronary artery disease.