Treatment of Diabetic Peripheral Neuropathy

Peripheral neuropathy is a common complication among patients with diabetes. Although several treatment options have been studied for diabetic peripheral neuropathy, the most optimal regimen or combination of agents has yet to be determined. Based on current data and recommendations, tricyclic antidepressants, serotonin/norepinephrine reuptake inhibitors, and gamma-aminobutyric acid analogs are recommended first-line agents, whereas opioids and topical treatments are second-line options.