Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice

Article ID	Journal	Published Year	Pages	File Type
5572139	Clinical Nutrition	2016	9 Pages	PDF

Abstract

Taken together, these findings suggest that glycine supplementation during CR may be beneficial for preserving muscle mass and stimulating loss of adipose tissue.

Keywords

mTOR Ccl5 BNIP3 HFD PPARD GTT eukaryotic translation initiation factor 2A ALA LC3B QUAD PPARA TNFa FOXO1 PPARG TBP MuRF1 eIF3F ATF4 eukaryotic translation initiation factor 3 Muscle RING finger-1 CCL2 IL-6 Foxo4 eIF2a AUC F4/80 alanine interleukin-6 con glucose tolerance test Nutrition Muscle mass fat mass tumor necrosis factor alpha Forkhead box O1 Least-squares method High fat diet LSM Sol Plan normalization factor Gastrocnemius muscle Soleus muscle Tibialis anterior muscle plantaris muscle Quadriceps muscle activating transcription factor 4 calorie restriction area under the curve Gast Mechanistic target of rapamycin TATA-box binding protein microtubule-associated protein 1 light chain 3 beta Peroxisome proliferator activated receptor alpha Control Gly Glycine Peroxisome proliferator activated receptor gamma

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Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice

Authors

Marissa K. Caldow, Daniel J. Ham, Daniel P. Godeassi, Annabel Chee, Gordon S. Lynch, René Koopman,