Incompatibilités médicamenteuses et nutrition parentérale en néonatologie

Drug administration in neonatology is challenging and may lead to preparation and administration difficulties associated with a high risk of drug errors. Concomitant administration of drugs and parenteral nutrition (PN), with or without lipid emulsion, is a common practice in the neonates. There is a high risk of physico-chemical incompatibilities with rare but serious consequences such as pulmonary and renal embolism. There is a lack of data on compatibility for the majority of drugs used for co-infusions in neonates. An individualized approach is required to manage drugs and PN administrations. Clinical pharmacists may help physicians and nurses in the unit to better understand and prevent drug incompatibilities.