High residual platelet reactivity - Does the problem persist even with new antiplatelet drugs?

High residual platelet reactivity (HRPR) in patients taking dual antiplatelet therapy (DAPT) is closely associated with serious ischaemic events, particularly in-stent thrombosis. Literature reports many cases of patients taking the combination of acetylsalicylic acid and clopidogrel with early in-stent thrombosis and the detection of high residual platelet reactivity, but cases in patients using a combination of new antiplatelet drugs are rare. The following case report presents the case of a patient with early in-stent thrombosis in whom HRPR was detected while he was on prasugrel therapy and describes the subsequent management of the complication.