| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5577946 | The Journal of Pain | 2017 | 37 Pages |
Abstract
Our findings provide, to our knowledge, the first evidence that downregulation of GABABRs contribute to the development and maintenance of CIBP and restored diminished GABABRs attenuate CIBP-induced pain behaviors at least partially by inhibiting the protein kinase/cAMP-response element-binding protein signaling pathway. Therefore, spinal GABABR may become a potential therapeutic target for the management of CIBP.
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Authors
Ya-Qun Zhou, Shu-Ping Chen, Dai-Qiang Liu, Anne Manyande, Wen Zhang, Shao-Bing Yang, Bing-Rui Xiong, Qiao-Chu Fu, Zhen-peng Song, Heike Rittner, Da-Wei Ye, Yu-Ke Tian,