| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5578006 | The Journal of Pain | 2017 | 31 Pages |
Abstract
Patients receiving chronic opioid are sensitive to cold. We show in mice and rats that sustained morphine administration induces cold hyperalgesia and an upregulation of TRPM8. Knockout or selectively blocking TRPM8 reduces morphine-induced cold hyperalgesia suggesting TRPM8 is regulated by opioids.
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Authors
Kerui Gong, Luc Jasmin,