Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5578124 | The Journal of Pain | 2017 | 40 Pages |
Abstract
We demonstrate that epigenetic regulation of OPRM1 contributes to opioid tolerance in cancer patients, and that targeted gene therapy could treat cancer-induced nociception and opioid tolerance in a mouse cancer model.
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Authors
Chi T. Viet, Dongmin Dang, Bradley E. Aouizerat, Christine Miaskowski, Yi Ye, Dan T. Viet, Kentaro Ono, Brian L. Schmidt,