Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5578179 | Journal of Pain and Symptom Management | 2017 | 19 Pages |
Abstract
When a standard full dose of a vasopressor fails to normalize blood pressure in a patient with septic shock, escalation begins to yield diminishing returns as the dose and multiplicity of agents approach practical upper limits. Although it is not possible to specify a precise cutoff for limiting vs. intensifying therapy, a mortality of 80% or higher-characterized by two or more concurrent vasopressors at full dose-should prompt shared decision making with the patient's family.
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Authors
Donald A. PhD, Patricia A. DrPH, Jeffrey T. MD, Mediha MD, Ajsza MD, Shweta MD, Peter MD,