Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5579482 | Seminars in Radiation Oncology | 2017 | 9 Pages |
Abstract
Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy. Technologic improvements have reduced the risk of normal tissue injury; however, toxicity causing treatment breaks or long-term side effects continues to occur in a subset of patients. The molecular events that lead to normal tissue injury are complex and span a variety of biologic processes, including oxidative stress, inflammation, depletion of injured cells, senescence, and elaboration of proinflammatory and profibrogenic cytokines. This article describes selected recent advances in normal tissue radiobiology.
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Authors
Deborah E. MD, James B. PhD,