Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5580246 | Anaesthesia & Intensive Care Medicine | 2017 | 4 Pages |
Abstract
Drug elimination is the removal of active drug from the body. Metabolism takes place largely in the liver and produces water-soluble metabolites which can be excreted in the bile or urine. Metabolism may also produce active or toxic metabolites or a pharmacologically active drug from an inactive prodrug. Most volatile anaesthetics are excreted unchanged via the lungs. Drug elimination can be affected by factors such as first-pass metabolism, genetic variants and various disease processes. Knowledge of these processes will allow better prediction of pharmacokinetics in practice.
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Authors
Shruti Chillistone, Jonathan G. Hardman,