Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5582028 | Clinical Lymphoma Myeloma and Leukemia | 2016 | 6 Pages |
Abstract
In this perspective, we examine the T-cell abnormalities in myeloma and postulate that, whereas cytotoxic T cells interacting with the tumor are dysfunctional, residual T cells still function adequately against external pathogens and thus protect patients from the infections normally associated with a generalized T-cell immunodeficiency state. The so-called 3 E's of host-tumor interaction (elimination, equilibrium, and escape) are clearly reflected in the immune landscape and clinical behavior of myeloma.
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Authors
Douglas Joshua, Hayley Suen, Ross Brown, Christian Bryant, P. Joy Ho, Derek Hart, John Gibson,