Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5583905 | Seminars in Arthritis and Rheumatism | 2017 | 27 Pages |
Abstract
Data from case-control studies do not support a link between IgG/IgM aPL and MS. Data from cohort studies comparing active vs stable MS indicate a strong link between aPL of IgM isotype and active/relapsing MS but in the absence of aPL titres to comment upon this may either represent an epiphenomenon of active neuro-inflammation or natural autoantibodies devoid of pathogenic potential. Data expressed as frequency of aPL positive participants rather than average titres preclude further assumptions.
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Authors
Mira MD, Joseâ² Delgado MD, PhD, Fabrizio MD, PhD, Paul R.J. MD, MSc, PhD,