Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5584843 | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) | 2017 | 13 Pages |
Abstract
Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFA) that are important regulators of kidney function and health. Targeted lipidomic analyses of renal oxylipins from four studies of rodent models of renal disease were performed to investigate the differential effects of dietary flax compared to fish oil, soy protein compared to casein, and sex. Across all studies, dietary fish oil was more effective than flax oil in reducing n-6 PUFA derived oxylipins and elevating eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived oxylipins, whereas dietary flax oil resulted in higher α-linolenic acid (ALA) oxylipins. Dietary soy protein compared to casein resulted in higher linoleic acid (LA) derived oxylipins. Kidneys from females had higher levels of arachidonic acid (AA) oxylipins, but similar or lower levels of oxylipins from other PUFA. Modulation of the oxylipin profile by diet and sex may help elucidate their effects on renal physiology and health.
Keywords
trihydroxy-octadecenoic acidDiHDPEHDoHEDiHETrEdihydroxy-docosahexaenoic acidDiHDoHEoxo-eicosatetraenoic acidHEPEdihydroxy-docosapentaenoic acidHETrEOxylipinsdihydroxy-eicosatrienoic acidDGLAGLAALAhydroxy-docosahexaenoic acidCOXTriHOMEoxo-octadecatrienoic acidCyPHOTrEepoxy-octadecenoic acidHODEcyclooxygenaseα-linolenic acidArachidonic acidOxo-octadecadienoic aciddocosahexaenoic aciddihydroxy-octadecenoic acidLinoleic acidHydroxy-octadecadienoic acidhydroxy-eicosatetraenoic acidhydroxy-eicosapentaenoic acidgamma-linolenic acidN-3 fatty acidsEpOMELOXthromboxaneSexDHAdihomo-gamma-linolenic acidDiHOMEResolvinFish oilFlax oilCytochrome P450lipoxygenaseBioactive lipidsHETESoy proteinprostaglandinKidney
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Authors
Jessay G. Devassy, Tamio Yamaguchi, Md Monirujjaman, Melissa Gabbs, Amir Ravandi, Jing Zhou, Harold M. Aukema,