| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5584905 | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) | 2017 | 23 Pages |
Abstract
In conclusion, BMP7, in particular combined with MSC, seems to have a favourable application also in periodontal regeneration. Our results show that inflammation plays an important role in periodontal regeneration. PGE2 is a key mediator, which stimulates bone resorption also via a mechanism involving the inhibition of osteogenic differentiation of MSC as well as PDLSC. Therefore, regenerative approaches should always be conducted in combination with anti-inflammatory measures oriented to control inflammation.
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Authors
Christina Ern, Tamara Berger, Iris Frasheri, Richard Heym, Reinhard Hickel, Matthias Folwaczny,