| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5585391 | Bone | 2017 | 26 Pages |
Abstract
- XLH, ADHR, ARHR, and tumor induced osteomalacia result in elevated FGF23 concentrations, causing hypophosphatemia.
- Iron deficiency increases FGF23 expression, but normal individuals cleave excess intact FGF23.
- α Klotho is a necessary co-receptor for FGF23.
- Excess circulating α Klotho increases FGF23 concentrations, resulting in hypophosphatemia.
- Deficiency in either intact FGF23 or α Klotho results in hyperphosphatemia.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Developmental Biology
Authors
Michael J. Econs,